Endocrine Abstracts

Background: Heterozygote mutations in the aryl hydrocarbon receptor-interacting protein (AIP) predispose carriers to young-onset pituitary adenomas, most often somatotroph or lactotroph adenomas. No other tumour type has been consistently detected in AIP mutation positive families, despite the fact that AIP is ubiquitously expressed. Current clinical and experimental data suggest that AIP is a tumour suppressor gene.Aims: To investigate the tumour suppre...

Acylation stimulating protein (ASP) synthesis occurs through the interaction between complement C3, factor B and adipsin in adipose tissue. ASP demonstrates potent lipogenic effects that are modulated by sex hormones in vivo and in vitro. In this study, an ex vivo investigation was carried out to analyse expression of genes related to ASP production and function. Adipose tissue was harvested from ovariectomized rats (n=6), and treated with s...

Background: Heterozygote germline mutations in the aryl-hydrocarbon receptor interacting protein (AIP) gene play a role in the pathogenesis of pituitary adenoma development in familial isolated pituitary adenoma as well as simplex pituitary adenoma cases. AIP mutation positive patients develop often aggressively growing tumours in early teenage years.Aims: The aim of this study was to perform comparative gene expression analysis of AIP mutation-positive ...